Neonatal sepsis remains one of the most important cause of mortality and morbidities in China. This study will establish a prospective registral cohort of all infants with culture-proven neonatal sepsis in Chinese NICUs participating in the Chinese Neonatal Network (CHNN). The microbiology, antimicrobial resistance patterns and neonatal outcomes will be described in detail for this cohort.
All infants with culture-proven sepsis in NICUs of CHNN will be enrolled in the study. Detailed data on microbiology, resistance pattern, neonatal mortality and morbidities will be collected and described. Risk factors for multi-resistant bacteria infections and for sepsis-related mortality will be identified.
Study Type
OBSERVATIONAL
Enrollment
1,200
This is a prospective observational cohort study. The purpose of the study was to compare the incidence of mortality, complications, and other outcomes between infants with multi-resistant bacteria sepsis and infants with sepsis caused by non-multi-resistant bacteria, and compare the incidence of complications and other outcomes between infants with sepsis-related death and infants who survive.
Overall mortality
Incidence of death during the study period
Time frame: About 3 months from admission to discharge or death
Sepsis-related mortality (within 7 days of sepsis)
Incidence of death within 7 days after sepsis
Time frame: About 3 months from admission to discharge or death
Incidence of multiorgan dysfunction
Propertion of infants who occur multiorgan dysfunction
Time frame: About 3 months from admission to discharge or death
Incidence of septic shock
Propertion of infants who occur septic shock
Time frame: About 3 months from admission to discharge or death
Incidence of respiratory failure
Propertion of infants who occur respiratory failure
Time frame: About 3 months from admission to discharge or death
Incidence of disseminated intravascular coagulation (DIC)
Propertion of infants who occur DIC
Time frame: About 3 months from admission to discharge or death
Incidence of renal failure
Propertion of infants who accur renal failure
Time frame: About 3 months from admission to discharge or death
Incidence of meningitis
Propertion of infants who accur meningitis
Time frame: About 3 months from admission to discharge or death
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Incidence of necrotizing enterocolitis
Propertion of infants who accur necrotizing enterocolitis
Time frame: About 3 months from admission to discharge or death
Incidence of brain injury
Propertion of infants who accur brain injury
Time frame: About 3 months from admission to discharge or death
Length of hospital stay
Days of hospitalization
Time frame: About 3 months from admission to discharge or death
Length of antibiotic treatment
Days of antibiotic treatment
Time frame: About 3 months from admission to discharge or death
Type and quantity of transfusion
Which kind and how much (ml) of blood product was used during the study
Time frame: About 3 months from admission to discharge or death