Cryotherapy in the Treatment of Desmoid Tumors

Istituto Ortopedico Rizzoli94 enrolled

Overview

Desmoid tumor is a benign neoplasm with an unpredictable course and a high rate of local recurrence if treated surgically. Therefore, over time the surgical approach has become conservative, preferring simple observation or medical therapy in case of disease progression through the use of hormonal therapy and low-dose chemotherapy. Since this neoplasm remains benign, our study aims to avoid chemotherapy in patients usually young through the use of a minimally invasive treatment such as cryotherapy.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Desmoid

Interventions

CryotherapyPROCEDURE

The procedure involves general or peripheral anesthesia and percutaneous treatment under CT control with probes capable of forming ice spheres of up to 3 cm that will be used in sufficient number to treat the neoplasm completely.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * histologic diagnosis of desmoid tumors * age \> 18 years * abdominal and extra-abdominal desmoid tumors Exclusion Criteria: * contraindication to the procedure by the interventional radiologist in terms of tumor proximity to neurologic/vascular structures * retroperitoneal desmoid tumors * age \< 18 years

Locations (1)

IRCCS Itituto Ortopedico Rizzoli

Bologna, BO, Italy

RECRUITING

Outcomes

Primary Outcomes

response to treatment

assessment of tumor response to treatment will be performed using the solid tumor response criteria

Time frame: At baseline (time 0)

Central Contacts

Costantino Errani, MD

CONTACT

051-6366 costantino.errani@ior.it

Data from ClinicalTrials.gov

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