Physiological Response to Prone Position in COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)

University of Lausanne Hospitals31 enrolled

Overview

Retrospective study in COVID-19 ARDS patients hospitalised in the ICU. Investigators aim to explore the effects of prone positioning on oxygenation, dead space ventilation and mortality.

Study Type

OBSERVATIONAL

Enrollment

Conditions

ARDS Sars-CoV-2 Infection

Interventions

Prone positioningPROCEDURE

Prone position during invasive mechanical ventilation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * COVID-19 associated moderate to severe ARDS * Invasive mechanical ventilation * Prone positioning * admitted to ICU Exclusion Criteria: * already sustained prone positioning in referring hospital * pronation during ECMO only * denied consent for data analysis

Locations (1)

Lausanne University Hospitals

Lausanne, Canton of Vaud, Switzerland

Outcomes

Primary Outcomes

PaO2/FiO2

Arterial partial pressure of oxygen / Fraction of inspired oxygen

Time frame: Within 2 hours before pronation and 2 hours before supination

Secondary Outcomes

Alveolo-arterial oxygen gradient change

Time frame: Within 2 hours before pronation and 2 hours before supination

Ventilatory Ratio

Time frame: Within 2 hours before pronation and 2 hours before supination

Mortality or Extracorporeal membrane oxygenation (ECMO) support

Time frame: Once between ICU admission and extubation

Data from ClinicalTrials.gov

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