Following injury or surgery to a limb, it is often immobilised to allow tissue healing. Short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. Strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (NMES), however at present its effectiveness is limited. Recent research suggests that the effects of NMES can be augmented with blood flow restriction (BFR). At present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. Furthermore, the impact of BFR training during retraining following immobilisation is unknown.
Following injury or surgery to a limb, it is often immobilised to allow tissue healing. Short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. Strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (NMES), however at present its effectiveness is limited. Recent research suggests that the effects of NMES can be augmented with blood flow restriction (BFR). At present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. Furthermore, the impact of BFR training during retraining following immobilisation is unknown. This study will examine the effectiveness and feasibility of a neuromuscular electrical stimulation and blood flow restriction protocol during a 7 day period of immobilisation. Multiple measures across several physiological systems will be obtained.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
36
Neuromuscular electrical stimulation with blood flow restriction
Change in maximal isometric strength via Biodex Dynamometer
Strength measure
Time frame: Through study completion, an average of 1 year
Change in maximal isokinetic strength via Biodex Dynamometer
Strength measure
Time frame: Through study completion, an average of 1 year
Change in muscle endurance via Biodex Dynamometer
Endurance measure
Time frame: Through study completion, an average of 1 year
Change in muscle morphology via 2D and 3D ultrasonography
Morphology measure
Time frame: Through study completion, an average of 1 year
Change in muscle VO2 via near-infrared spectroscopy
VO2 measure
Time frame: Through study completion, an average of 1 year
Change in blood markers via venous blood samples
Blood markers
Time frame: Through study completion, an average of 1 year
Change in pressure pain thresholds via handheld allometry
Pain measure
Time frame: Through study completion, an average of 1 year
Change in corticomotor excitability and inhibition, via transcranial magnetic stimulation
Corticospinal function
Time frame: Through study completion, an average of 1 year
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