Effects of Single Dose Tadalafil on Urethral and Anal Closure Function

Inclusion Criteria: * Signed informed consent form * Normal weight (Body weight 50 kg or more, Body Mass Index 18-5-30 kg/m2) * Sexual abstinence or use of safe contraceptive methods i.e. intrauterine devices, hormonal contraception (oral contraceptive pills, implants, transdermal patches, vaginal rings or long acting injections), or surgically sterilized partner throughout the course of the study and until six days after the study has ended for the subject. Women who are postmenopausal (defined as no menstrual periods for 12 months or more prior to enrolment) can be included without use of contraceptive methods. * Presentation of a negative urine human chorionic gonadotropin (hCG) urine pregnancy test prior to dosing (on both study days) Exclusion Criteria: * History of clinically significant urinary incontinence. * Current acute or chronic condition, unless considered clinically irrelevant and stable by the investigator. * Average systolic blood pressure \<100 mmHg or \>140 mmHg and/or average diastolic blood pressure \<60 mmHg or \>90 mmHg (average of three measurements performed at screening). * Average pulse \< 40 or \> 100 beats/minute (average of three measurements performed at screening). * Pregnancy within 6 months before screening and throughout the study period. * Breastfeeding throughout the study period and 6 days after study day 2. * Any systemic drug use within 2 weeks before first study drug administration (prescription drugs, over-the-counter drugs, herbal drugs and illicit drugs), except for occasional use of paracetamol (up to 4 g/day), hormonal contraceptives and hormone replacement therapy. * Smoking or other regular use of any form of nicotine product during the study period and the previous 3 months. * Alcohol consume 24 hours prior to dosing. * Current or prior participation (within 3 months before screening) in other clinical trials that might affect the results of this study (judged by the investigator).