The Role of Genetic Factors in the Development of Idiopathic Osteoarthritis of the Knee in the Kazakh Population

Inclusion Criteria: 1. Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years; 2. Representatives of the Kazakh ethnic group up to the 3rd generation; 3. Hereditary history of arthrosis; 4. Persons who are able and willing to provide written informed consent; Exclusion Criteria: 1. Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age; 2. Representatives of other ethnic groups; 3. Representatives of the Kazakh ethnic group less than 3 generations; 4. No family history of bilateral idiopathic gonarthrosis; 5. Patients with an acute period of the inflammatory process (laboratory and clinical signs); 6. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; 7. Pregnant or lactating women; 8. Tuberculosis of any localization in the active phase and in history; 9. Severe and decompensated diseases of the liver and kidneys, cardiovascular system; 10. Severe and decompensated course of endocrine diseases; 11. Autoimmune diseases; 12. Systemic diseases; 13. Oncological diseases;