Study of the Prognostic Role of Gene Polymorphism in the Development of B-cell Leukemias and Lymphomas in Children of Kazakh Nationality

Asfendiyarov Kazakh National Medical University400 enrolled

Overview

To search for a genetic marker of B-cell leukemias and lymphomas in children of Kazakh nationality, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with B-cell leukemias and lymphomas in children of Kazakh nationality and normal control will be performed.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

B Cell Leukemia Lymphoma

Interventions

SNP analysis of the DNAGENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Eligibility

Sex: ALLMin age: 0 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ethnicity - Kazakhs in at least three generations * active disease or a history of B-line ALL or B-NHL, established on the basis of morphological, cytochemical, immunophenotypic or immunohistochemical research methods with confirmation of the fact of the disease in medical documentation * Signed voluntary informed consent of the legal representative to participate in the project Exclusion Criteria: * Children suffering from other types of malignant neoplasms * Children with B-linear leukemia and lymphomas with concomitant specified genetic and chromosomal diseases * Children of non-Kazakh nationality * Absence of signed informed consent or informed refusal of the legal representative to participate in the study before starting therapy

Locations (1)

Scientific Center of Pediatrics and Pediatric Surgery

Almaty, Kazakhstan

Outcomes

Primary Outcomes

Associated with B-cell lymphoma and B-cell acute lymphoblastic leukemia

Genotype frequency of SNP in the study genes of participants and control participants.

Time frame: 1 year

Data from ClinicalTrials.gov

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