Hepatocellular Carcinoma Imaging Using PSMA PET/CT

Inclusion Criteria: * Male or female aged 18 years or older at screening * Has provided written informed consent for participation in the study * Must have risk factors for HCC e.g. cirrhosis, chronic hepatitis B infection with or without cirrhosis * Patients with liver lesions ≥1 cm suspicious for HCC but with indeterminate features on CT and MRI meeting LI-RADS 3 or 4 criteria planned for biopsy, OR patients with liver lesions diagnostic of HCC based on CT or MRI meeting LI-RADS 5 criteria planned for surgical resection * Patients must be willing and able to comply with the protocol and procedures for the duration of the study * Patients must be available for follow-up Exclusion Criteria: * Abdominal surgery or radiotherapy to the abdomen within \<4 weeks of registration. Patients must have recovered from any effects of any major surgery * Uncontrolled intercurrent illness that is likely to impede participation and or compliance * Any history of prostate cancer or elevated PSA level for male patients * Other malignancies unless curatively treated with no evidence of disease within previous 3-years other than adequately treated non-melanoma skin cancer or melanoma in situ * Participation in another clinical study with an investigational product or another systemic cancer therapy administered in the last 4 weeks * Has known psychiatric or substance abuse disorders that would interfere with cooperation with requirements of the study * Women who are pregnant or lactating * Cirrhosis due to congenital hepatic fibrosis, vascular disorders (e.g. Budd-Chiari syndrome) or cardiac cirrhosis