Compare the Safety and Efficacy of Genoss® DCB and SeQuent® Please NEO in Korean Patients With Coronary De Novo Lesions

Inclusion Criteria: * Age ≥19 years old * Patients requiring PCI with coronary de novo lesions * Patients with stable angina pectoris, or unstable angina pectoris, and asymptomatic myocardial ischemia * Women of childbearing age who agreed to use one or more of the clinically appropriate methods of contraception during the trial period. * In case of voluntarily deciding to participate in this clinical trial by signing the informed consent form Inclusion criteria for coronary angiography * Patients with significant coronary artery stenosis (\> 50% diameter stenosis on coronary angiography) * On coronary angiography, the length of the lesion is less than 34 mm and the diameter of the reference vessel of the coronary artery is 2.0 - 4.0mm. Exclusion Criteria: * Patients with ST-segment elevation myocardial infarction (STEMI) * Patients who are contraindicated in aspirin, heparin, ticagrelor, iopromide, clopidogrel, prasugrel and paclitaxel * Patients with platelet aggregation or disorders at risk of increased bleeding, such as gastrointestinal ulcers, which limit platelet aggregation inhibitory therapy and anticoagulant therapy * Patients with a left ventricular ejection fraction of less than 30% on echocardiography * Patients with renal insufficiency (eGFR\<30mL/min) * Patients with a history of cardiogenic shock * Pregnant or lactating women * The patients have a life expectancy of less than 12 months * Patients who have or currently have medical conditions such as psychiatric disorders that significantly affect this clinical trial * Patients who, in the investigator's judgment, may not be suitable for this clinical trial or may increase the risk associated with participation in the study * Patients who are currently participating in other clinical trials or have experience participating in other clinical trials within 90 days from the screening date * Patients who are unsuitable for the study according to the investigator judges Exclusion criteria for coronary angiography * Patients with left main coronary lesion * Patients with graft vessel lesion * Patients who cannot apply pre-dilation or fail in pre-dilation to apply medical devices for clinical trials * Patients with one of the following items after pre-dilation of the target lesion * When FFR (Functional measurement) is measured as ≤ 0.8 in large vessels with a reference vessel diameter exceeding 2.75mm (However, depending on the judgment of the investigator, FFR measurement may not be performed.) * Patients who need stenting due to vascular dissection that restricts blood flow * Residual stenosis \> 30% * TIMI flow \< 3