Acute pancreatitis (AP) is a one of the potentially life-threatening complication of severe hypertriglyceridemia (HTG), with mortality around to 30%. HTG-associated PA and their complications management has to be the same as the other pancreatitis, but they are associated with the worse clinical outcomes. Triglycerides levels are correlated with the risk of pancreatitis and severity. Therapeutic plasma exchange (TPE) could provide positive effects in reducing triglyceridemia plasma levels during the acute phase of HTG-AP, and in prevention of recurrence. There is currently no difference about mortality in studies. Some authors have recommended its use only in severe HTG-AP and have precised the need of early initiation to have positive results. Despite such promising findings from studies, the effects of therapeutic plasma exchange on HTG-associated PA have never been specifically assessed and its benefits in critically ill patients with AP remains uncertain.
Study Type
OBSERVATIONAL
Enrollment
100
CHU de Nîmes - Hôpital Universitaire Carémeau
Nîmes, France
Mortality at Day 28
Assess the factors on admission associated with the prognosis of patients admitted in ICU for HTG-associated PA. Factors associated with death at D28 will be considered individually for entry into a multivariate model. The following variables of interest will be tested in the model: SOFA score, triglyceride level at admission, obesity.
Time frame: Day 28
Length of hospitalization
Describe length of stay in ICU and on hospital for patients admitted in ICU for HTG-associated PA
Time frame: Day 28
Use of organ support
Describe use of organ supports (vasopressors, extra-renal dialysis and mechanical ventilation)
Time frame: Day 28
Assess benefit of plasmapheresis
Assess benefit of plasmapheresis for patients admitted in ICU for HTG-associated PA
Time frame: Day 28
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