The aim of the study is to determine if PET-CT imaging (using contrast recommended in clinical guidelines) is superior to combined bone scan and MRI/CT of the abdomen \& pelvis in detecting the increased incidence of metastasis (nodal/distant outside the pelvis) in men with prostatic carcinoma with mutations in any of the following germline DNA repair genes BRCA1, BRCA2, MSH2, MSH6, MLH1, PMS2, CHEK2, PALB2, ATM.
Study Type
OBSERVATIONAL
Enrollment
50
Individuals to undergo a clinical MRI or CT scan of Pelvis and the study reviews the images.
bone scan of the whole body (under clinical diagnosis).
Pt will undergo a PET-CT for their clinical treatment and we will review the images of this scan.
Cancer Genetics Unit, Royal Marsden Hospital
London, Sutton, Surrey, United Kingdom
RECRUITING1. Sensitivity of FCH-PET-CT scan
To determine if the sensitivity of FCH-PET-CT is superior to combined conventional imaging (MRI (T2 and T1 weighted)/CT and bone scan) in detecting nodal and distant (outside the pelvis) metastases in BRCA1/2 germline mutation carriers with prostate cancer.
Time frame: Within 12 months of the last FCH-PET-CT scan
2. Outline the Specificity of the FCH-PET-CT scan
determining the positive predictive value (PPV) and negative predictive value (NPV) in detecting metastatic disease in BRCA mutation carriers with prostate cancer
Time frame: Within 12 months of the last FCH-PET-CT scan
Metastasis Incidence
3.Incidence and sites of additional metastases identified on FCH-PET-CT compared with combined MRI/bone scan.
Time frame: Within 12 months of the last FCH-PET-CT scan
Impact of FCH-PET-CT findings
To measure the impact of FCH-PET-CT findings in changing patient management and in clinical decision making
Time frame: Within 12 months of the last FCH-PET-CT scan
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