Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.
We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
10
HFNC provides humidified, heated, oxygen-enriched air at constant concentration with a flow up to 60L/min through a nasal cannula. It washouts the anatomical dead space and decreases the work of breathing.
VM is commonly used by COPD patients during exercise training.
Shiying
Guangzhou, Guangdong, China
RECRUITINGEndurance time
Endurance time for 10 minute steping test
Time frame: 10 minute
Respiratory pattern
Respiratory pattern is calculated by the flow and time
Time frame: 10 minute
Work of breathing
Work of breathing is calculated by the transdiaphragmatic pressure
Time frame: 10 minute
Neural respiratory drive
Neural respiratory drive is calculated by diaphragm electromyogram
Time frame: 10 minute
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