The purpose of this study is to investigate whether or not furosemide causes the bladder to fill faster than IV fluids alone so that a pelvic ultrasound exam can be performed.
Trans-abdominal pelvic ultrasound is the standard imaging modality for diagnosis of ovarian torsion in the pediatric population, however this requires that the patient have a full bladder at the time of imaging. This study will investigate whether low dose furosemide in addition to IV fluid boluses may provide a fast, effective, and non-invasive means to fill the bladder of pediatric females awaiting pelvic US. The target population are females age 8 to 18 years seen in the emergency room at Connecticut Children's Medical Center who are undergoing a trans-abdominal pelvic ultrasound to assess for ovarian torsion. Enrolled patients will be randomized to the control (IVF bolus only) group vs. the intervention (IVF bolus + furosemide) group and will undergo point-of-care US (POCUS) and bladder scanner evaluation of the bladder every 30 minutes until the bladder is determined to be full.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
42
0.1mg/kg (max 5mg) of IV furosemide
20mL/kg (max 1000mL) normal saline bolus plus a normal saline flush
Connecticut Children's Medical Center
Hartford, Connecticut, United States
The time from initiation of the intervention to the time that the bladder reaches large, ovoid shape on POCUS exam
Initiation of the intervention is defined as administration of furosemide vs. normal saline flush.
Time frame: Through study completion, about 3 hours
The correlation between bladder volume as calculated on POCUS exam of a large, ovoid bladder and bladder volume as reported by bladder scanner
Measurements will be completed every 30 minutes through study completion
Time frame: Through study completion, about 3 hours
Number and nature of all reports of adverse events related to furosemide administration
Adverse events include signs of severe dehydration, allergic reaction, and electrolyte abnormality
Time frame: From time of intervention until final disposition, about 6 hours
The time from initiation of the intervention to the time of completion of successful radiology-performed pelvic US
Time frame: About 3 hours
The time from initiation of intervention to the time of admission or discharge order placement
Time frame: From time of intervention until final disposition, about 6 hours
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