Intraoperative Different Concentrations Oxygen And Oxidatıve Stress Markers

Zonguldak Bulent Ecevit University40 enrolled

Overview

The aim of the study was to assess the effect of intraoperative oxygen (O2), which was applied at 30% and 50% concentrations on patients who had undergone septoplasty surgery, on Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Stress Hyperoxia

Interventions

taking arterial blood sample through the injectorPROCEDURE

taking blood samples from patients applied with different oxygen concentrations

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients aged between 18-60 years, * ASA I-II risk class with a minimum operative time of 1.5 hour(s) for whom septoplasty operation under elective conditions Exclusion Criteria: * metabolic, endocrine, hepatic, cardiac, or renal diseases, * malignancies and who used a drug with antioxidant properties such as vitamin E-C * acetylcysteine in the last 48 hours, * patients requiring intraoperative 100% O2 inhalation

Locations (1)

Zonguldak Bülent Ecevit University

Zonguldak, Kozlu, Turkey (Türkiye)

Outcomes

Primary Outcomes

EFFECTS OF INTRAOPERATIVE OXYGEN USED AT DIFFERENT CONCENTRATIONS ON OXIDATIVE STRESS MARKERS

TAS and TOS values occurring at different oxygen concentrations

Time frame: end of the surgery

Data from ClinicalTrials.gov

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