Interleukin 4 and Interferon Gamma Predictors of Human Papillomavirus Immunotherapy in Warts

Zagazig University80 enrolled

Overview

In the present study the investigators assessed the invitro role of IL-4 and IFN-γ in predicting the response to bivalent HPV vaccine after whole blood stimulation

40 Patients and 40 controls are enrolled in the study. Participants suffer from chronic recurrent cutaneous and genital warts. Blood samples were withdrawn then whole blood cultures are prepared. Cultures are stimulated with bivalent HPVvaccine. IL-4 and IFN-γ measurement in culture supernatants by ELISA. IL-4 and IFN-γ are investigated to predict the therapeutic response to bivalent HPV vaccine immunotherapy in warts.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Warts Hand Wart, Genital

Interventions

IL-4 and IFN-γ measurementsBIOLOGICAL

Blood samples are withdrawn from participants and whole blood cultures are prepared and stimulated by bivalent HPV vaccine.IL-4 and IFN-γ are measured in culture supernatants

Eligibility

Sex: ALLMin age: 36 Months

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with recurrent and recalcitrant cutaneous and anogenital warts. Exclusion Criteria: * History of allergy to the HPV vaccine * Active viral, fungal, or bacterial infections * Immunosuppressive diseases or drugs. * Autoimmune diseases, or other systemic diseases, e.g., hepatic, or renal disorders, diabetes, meningitis or convulsions * Skin allergies * Pregnancy and lactation * Earlier wart treatment at least one month before enrollment.

Locations (1)

Zagazig University Faculty of Medicine

Zagazig, Sharqia Province, Egypt

Outcomes

Primary Outcomes

Change of IFN-γ and IL-4 levels

Quantitative measurement of IFN-γ and IL-4 in culture supernatants

Time frame: 48 hours

Secondary Outcomes

Change in the size of warts

Clinical observation and photographing of wart size

Time frame: 6 months

Data from ClinicalTrials.gov

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