Platelet Rich Fibrin and Concentrated Growth Factors on Osseointegration of Immediate Implants

N/ACompletedNCT05101954

Hams Hamed Abdelrahman14 enrolled

Overview

This study will involve 14 patients with mandibular premolars indicated for extraction and immediate replacement. The patients will be randomly allocated into two groups and each patient will receive one implant. In Group A, a CGF membrane will be laid in the implant cavity. While in Group B, a PRF membrane will be laid in the implant cavity. Bone graft material will be applied to fill the empty parts of the socket. Resonance frequency measurement will be done using the OSTELL device intraoperatively, at the 1st week and after 3 months. Cone-beam computed tomography will be done preoperatively, immediately following surgery, and after 3 months

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Tooth Extraction Dental Implants

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Cooperative patients with good oral hygiene. * Patients having a history of mandibular premolars indicated for extraction and immediate replacement. Exclusion Criteria: * Heavy smokers. * Parafunctional occlusal habits. * Uncontrolled diabetes. * History of chemotherapy or radiotherapy. * Hematological disorders that prevent either implantation or centrifugation. * Pregnancy. * The nee¬d for additional augmentation or previous augmentation of the same region. * Chronic periapical pathology

Outcomes

Primary Outcomes

Change in implant stability

Osstell instrument (Integration Diagnostics, Goteborg, Sweden) with Smartpeg™ (Integration Diagnostics, Goteborg, Sweden), a transducer suitable for implants will be used to assess stability of implants by RFA. ISQ (implant stability quotient) will be obtained from the measurement results. During measurement, the Smartpeg™ will be placed over the location of implant prosthesis and the Osstell probe will be approximated to it from the buccal, palatal, mesial and distal aspects of the implant giving four ISQ values. A mean ISQ for each implant is then calculated by averaging the four values. The ISQ values of the implants will be measured during the operation, at the first week and three months after the operation.

Time frame: immediately, at 1 week, at 3 months

Change in Bone density

The Patients will be asked to do CBCT immediately after surgery and after 3 months

Time frame: immediately, after 3 months

Change in bone formation

Amount of bone formed buccal and lingual to the implant will be assessed using CBCT

Time frame: immediately, after 3 months

Marginal bone loss

it will be assessed using CBCT

Time frame: after 3 months