Mechanical ventilation is likely lifesaving in patients with coronavirus disease 2019 (COVID-19) but may also result in adverse events. Only few studies describe the strategies used and adverse effect of mechanical ventilation in an unselected population of ICU patients with COVID-19. This study is designed to be a retrospective study focusing on all mechanical ventilated ICU patients with COVID-19 included in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e. a total of 1,193 patients. The investigators will register the use of the core interventions around mechanical ventilation and its potential adverse event, including barotrauma and prolonged ventilation. This study will provide important data on the ventilation strategies used and its potential adverse events in unselected ICU patients with COVID-19 and thereby inform clinicians, patients, policy-makers, and future research in this area.
Study Type
OBSERVATIONAL
Enrollment
1,193
Department of Anaesthesiology and Intensive Care Medicine, Aalborg University Hospital
Aalborg, Denmark
RECRUITINGDepartment of Anesthesiology and Intensive Care, Kolding Hospital
Kolding, Denmark
RECRUITINGVentilator days with lung -protective ventilation in percent of all ventilation days with 95%-CI.
Low tidal volume ventilation (Vt 4-8 mL/kg of predicted body weight)
Time frame: Until 90 days
Pneumothorax
Pneumothorax noted in the medical record
Time frame: Until 90 days
Ventilator days
Number of days where the patients where the patient is ventilator depended
Time frame: Until 90 days
Number of patients with prolonged ventilation
Patients with more than 30 ventilator days
Time frame: Until 90 days
paO2/FiO2 ratio on days of ventilation
Ratio between measured arterial oxygen pressure and the fraction of inhaled oxygen
Time frame: Until 90 days
The use of APRV
The use of Airway pressure release as primary ventilator setting
Time frame: Until 90 days
Prone position
The use of prone position within the first 3 days and the use of prone position after day 3
Time frame: Until 90 days
Time to spontaneous ventilation
Time measured in days until the patients no longer needs controlled ventilation
Time frame: Until 90 days
Tracheostomy
Day after first intubation, Percutaneous dilatational tracheostomy (y/n), Surgical tracheostomy (y/n)
Time frame: Until 90 days
Adjuvant drugs
Adjuvant drugs at any time during mechanical ventilation
Time frame: Until 90 days
Mortality
Mortality at day 90
Time frame: Until 90 days
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