Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity

Azienda Sanitaria-Universitaria Integrata di Udine170 enrolled

Overview

Awake craniotomy require a cooperative patient during resection neurosurgery phase. Anesthesiologist should guarantee analgesia, sedation, nausea and vomiting prevention, while maintaining normal vital parameters. Neurosurgeon could be help by Intraoperative electrocorticography to maximise lesion resection and avoiding neurologic sequelae. Propofol and remifentanyl have been largely used. Dexmedetomidine represents an alternative. However little is known about the role of dexmedetomidine on Intraoperative electrocorticography.

Study Type

OBSERVATIONAL

Enrollment

170

Conditions

Craniotomy Seizures Dexmedetomidine Propofol Remifentanil Cerebral Tumor Neurophysiology

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * PATIENTS UNDERGOING AWAKE CRANIOTOMY FOR TUMOR RESECTION (EXCLUDED E.G. SURGERY OF EPILEPSIA) * INTRAOPERATIVE MONITORING (IOM) WITH ELECTROCORTICOGRAPHY * AWAKE-AWAKE-AWAKE TECHNIQUE Exclusion Criteria: * AGE \<18 YEARS OLD * NON AWAKE-AWAKE-AWAKE TECHNIQUE * ABSENCE OF IOM

Outcomes

Primary Outcomes

SEIZURE ACTIVITY

INCIDENCE OF ELECTRO-CLINICAL SEIZURE ACTIVITY IN THE TWO GROUPS DURING RESECTIVE PHASE OF AWAKE CRANIOTOMY EVALUATED WITH ELECTROCORTICOGRAPHY.

Time frame: DURING TUMOR RESECTION PHASE OF THE AWAKE CRANIOTOMY