Hemostatic Patch/Collagen Sealant and Polyethylene Glycol (Hemopatch) in the Postoperative of the Thyroidectomy.

Inclusion Criteria: * Patients of legal age. * Indication of total thyroidectomy due to multinodular goiter. * Accept to enter the study and sign the informed consent. * Patient willing and able to complete clinical trial procedures, as described described in the protocol. Exclusion Criteria: * Patients under 18 years of age. * Patients with surgical indication for hemithyroidectomy or subtotal thyroidectomy (eg unilateral nodular goiters). * Multinodular goiter with high suspicion or preoperative diagnosis of cancer (Bethesda V and VI and / or infiltration of neighboring structures on imaging tests). * Known allergy or hypersensitivity to a component of the Hemopatch® investigational treatments, riboflavin, or bovine proteins. * Concurrent or prior therapy with systemic pharmacological agents that promote blood clotting, including, but not limited to, tranexamic acid, activated factor VII, fibrinogen, and aprotinin. * Pregnancy or breastfeeding. * Refuse to enter the study and sign the informed consent. * Not agreeing to carry out all the planned follow-up. * Concurrent participation in another clinical trial with a medical device or drug or with interfering endpoints Inability to understand the nature and scope of the trial and the required procedures. Criteria to be verified during surgery (Intraoperative exclusion criteria): * Persistent major bleeding after primary hemostasis. * Infection of the surgical area.