the impact of donor-recipient ABO matching on outcome of peripheral blood stem cell haploidentical hematopoietic stem cell transplantation
The impact of donor-recipient ABO compatibility on transplant outcomes had been evaluated in different transplant settings, but had shown different results. The investigators set out to investigate the impact of ABO incompatibility on post-transplant outcomes, engraftment kinetics and blood product requirements, transfusion independence, the incidence of poor graft function (PGF) in anti-T-lymphocyte globulin (ATG) based haplo-SCT with PBSC grafts.
Study Type
OBSERVATIONAL
Enrollment
510
no intervention, just observation
The first Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China
Affiliated Jinhua hospital of Zhejiang University
Jinhua, Zhejiang, China
5-year Overall Survival
5-year Overall Survival
Time frame: 5 year
5-year Non-relapse mortality
5-year non-relapse mortality
Time frame: 5 year
5-year cumulative incidence of chronic graft versus host disease
5-year cumulative incidence of chronic graft versus host disease
Time frame: 5 year
28-day cumulative incidence of neutrophils engraftment
numbers of participants achieved neutrophils engraftment at 28 days post transplantation
Time frame: 28 day
28-day cumulative incidence of platelets engraftment
numbers of participants achieved platelets engraftment at 28 days post transplantation
Time frame: 28 day
365-day blood transfusion requirements
numbers of blood products transfusion within 365-day after transplantation
Time frame: 365 day
cumulative incidence of blood transfusion independence within 60 days after transplantation
numbers of participants achieved blood transfusion independence within 60 days after transplantation
Time frame: 60 day
the 5-year cumulative incidence of poor graft function the incidence of poor graft function
numbers of participants occurred poor graft function 5 years post transplantation
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Time frame: 5 year
the 5-year cumulative incidence of graft failure
numbers of participants occurred graft failure 5 years post transplantation
Time frame: 5-year
100-day cumulative incidence of acute graft versus host disease
100-day cumulative incidence of acute graft versus host disease
Time frame: 100-day