Eplerenone Versus PDT: Comparative Study by OCTA

Federico II University30 enrolled

Overview

The study aims to analyze the changes in OCTA parameters and in choroidal thickness in patients affected by central serous chorioretinopathy treated by oral eplerenone and half-fluence photodynamic therapy.

Central serous chorioretinopathy (CSC) is a chorioretinal disease characterized by serous detachment due to the dilatation and hyperpermeability of choroidal vessels resulting in the accumulation of serous fluid between the neurosensory retina and the retinal pigment epithelium. Several studies reported the efficacy of half-fluence photodynamic therapy (PDT) and oral eplerenone in the CSC treatment inducing a reduction of the choroidal hyperpermeability and remodeling the choroidal vascularization. This retrospective study aims to perform a quantitative analysis of retinal and CC vessel density by OCTA at baseline, 3 and 6 months in patients underwent PDT and patients underwent eplerenone.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Central Serous Chorioretinopathy

Interventions

EplerenoneDRUG

The patients underwent eplerenone treatment for 6 months

The patients underwent half fluence photodynamic therapy for 6 monthsDEVICE

Half fluence photodynamic therapy for 6 months

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age older than 30 years * diagnosis of central serous chorioretinopathy * treatment-naïve with half-fluence photodynamic therapy or oral eplerenone * absence of vitreoretinal and vascular retinal diseases Exclusion Criteria: * age younger than 30 years * absence of diagnosis of central serous chorioretinopathy * previous treatment with half-fluence photodynamic therapy or oral eplerenone * presence of concomitant vitreoretinal and vascular retinal diseases

Outcomes

Primary Outcomes

Study of vessel density in retinal choriocapillaris networks, using OCTA, in patients underwent half fluence photodynamic therapy and oral eplerenone

To evaluate the role of optical coherence tomography angiography in predicting the changes of the vessel density of retinal and choriocapillaris vascular networks , comparing patients underwent half-fluence phodynamic therapy and patients with oral eplerenone. The vessel density are expressed as percentage

Time frame: 6 months

Data from ClinicalTrials.gov

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