Correlation Between Optical Coherence Tomography Angiography and Photopic Negative Response in Patients With Glaucoma

Benha University76 enrolled

Overview

Open angle glaucoma (OAG) is considered a common cause of irreversible vision loss worldwide. It is an optic neuropathy associated with progressive loss and degeneration of the retinal ganglion cell layer (RGC) and its axons (retinal nerve fiber layer; RNFL), which lead to neuroretinal rim excavation and corresponding visual field defects. OCT Angiography (OCTA) is a promising tool for diagnosing and monitoring glaucomatous patients. It can evaluate glaucomatous damage and assess the ganglion cells' health by measuring blood flow within the optic nerve and the retina Correlation between vascular , structural and functional changes of the peripapillary retinal nerve fiber (RNFL) and macular/ganglion cell complex (GCC) can lead to early detection of glaucomatous changes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Open Angle Glaucoma

Interventions

Optical Coherence Tomography- AngiographyDIAGNOSTIC_TEST

Peripapillary retinal nerve fiber layer thickness, ganglion cell complex, superficial and deep capillary plexus vessel density were measured.

Photopic negative responseDIAGNOSTIC_TEST

Both the implicit time and amplitude of PhNR were recorded.

Eligibility

Sex: ALLMin age: 35 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age of 30 years or older for both control and glaucoma groups. * Spherical equivalent (SE) between -2 and +2 D. * No history of previous eye surgery, trauma, or systemic diseases. Exclusion Criteria: * Spherical equivalent greater than +/- 2.00 diopters (D). * Media opacity as (cataract or corneal scar). * Any history of ocular surgeries or trauma. * Optic nerve anomaly or other retinal diseases. * Unreliable visual field tests (33% fixation losses, false positive, and false- negative results).

Locations (1)

Benha University

Banhā, Benha, Egypt

Outcomes

Primary Outcomes

Correlation between vascular, structural and functional changes of the peripapillary retinal nerve fiber and macular ganglion cell complex in patients with open angle glaucoma.

Correlation between RNFL thickness and GCC measured by OCT-A with implicit time and amplitude of Photopic Negative Response (PhNR) measured by electroretinogram.

Time frame: Immediately after OCTA and electroretinogram diagnostic tests for each eye.

Secondary Outcomes

Assess the validity of OCTA parameters and PhNR in early detection of glaucoma changes.

Changes in the parameters were measured by OCT-A as Superficial and deep vessel Density.

Time frame: Immediately after OCTA and electroretinogram diagnostic tests for each eye.

Data from ClinicalTrials.gov

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