The study will examine whether inhibition of the pre-supplementary motor area (pSMA) using transcranial magnetic stimulation (TMS) normalizes activity in pSMA-connected circuits, improves response inhibition, and reduces compulsions in adolescents with OCD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
7
All teens will receive active TMS; they will be randomly assigned to receive active TMS at either visit 1 or visit 2 (order counterbalanced)
Emma Pendleton Bradley Hospital
Riverside, Rhode Island, United States
Change in Response Time on Stop Trials of the Stop Signal Task
Computerized task, where shorter response time (in milliseconds) indicates better performance
Time frame: Change from pre (within 1 hour before) to post (within 1 hour after) intervention
Change in Frontocentral P3 Amplitude on Electroencephalogram (EEG)
Electroencephalogram (EEG) measured amplitude on successful stop trials of the stop signal task (SST). Calculated by averaging the epochs of successful stop trials time-locked to the stop signal from the midline electrode (Cz).
Time frame: Change from pre (within 1 hour before) to post (within 1 hour after) intervention
Self-report Symptom Question
Self-rated compulsions on a single-item 0-5 scale, where higher scores indicate more compulsions
Time frame: post (within 1 hour after) intervention
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