Human resolutive macrophages are essential immune cells in the resolution of inflammation. This particular type of macrophages remains poorly known and currently there are no biomarkers to identify them in vivo. Within UMR1098-RIGHT, specific biomarkers (secreted molecules and membrane receptors) of human resolutive macrophages (healthy volunteers) have been identified in vitro, but their existence in vivo remains an outstanding issue. An exploratory study (lack of data from the literature) will validate the ex vivo expression of these markers in samples of patients whose inflammation is not, or little, supported by the available therapies (NSAIDs, biotherapies, corticosteroids).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
blood sample collected by peripheral blood mobilization joint fluid collected by punction gingival exudate collected with paper strips
CHRU Besançon
Besançon, France
RECRUITINGDentist'S Office
Montbéliard, France
RECRUITINGQuantification of cytokine concentrations in samples by ELISA
Time frame: up to 2 months
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