Denosumab vs Zoledronic Acid and Osteoporotic Compression Fracture

Inclusion Criteria: * Must be age between 40 and 90 years old * X-ray diagnosis of 1-2 vertebral compression fractures * Dual eneragy X ray test for bone mineral density T value less than -1 * fracture history lasted within 6 weeks * Must be MRI showed bone marrow edema of injured segment * Must be lower back pain, local spines tenderness Exclusion Criteria: * Must be able to have no posterior vertebral wall fracture * Must be able to have no patients with intervertebral fissure * Must be able to have no infection * Must be able to have no malignancy * Must be able to have no neurological dysfunction * Must be able to have no calcium level ≤2.13 mmol/L * Must be able to have no previous use of anti-osteoporosis drugs * Must be able to have no inability to perform magnetic resonance imaging * Must be able to have no prior back surgery * Must be able to have no other established contraindications for elective surgery