* 2D Echocardiography with color Doppler assessment: It will be done within 24 h after PPCI * Peripheral blood samples were obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level. * Follow up 2D Doppler echocardiography: will be repeated at 40 days of the event.
2D Echocardiography with color Doppler assessment: It will be done within 24 h after PPCI. Measurements will be as following: 1. Pulsed wave (PW) Doppler will be performed in the apical 4chamber view within a 3 mm sample volume at the tip of the mitral leaflets to obtain mitral inflow velocities to assess LV filling. 2. E (early diastolic)/A (late diastolic) - Using PW Doppler, the peak E and A velocities were recorded, then the ratio of E/A will be calculated. 3. IVRT (isovolumic relaxation time) - derived by placing the cursor of Continuous wave (CW) Doppler in the LV outflow tract to simultaneously display the end of aortic ejection and the onset of mitral inflow. 4. Deceleration time (DT) - from the peak of E wave to baseline. 5. E/e'- PW tissue Doppler imaging (TDI) was performed in the apical views to acquire mitral annular velocities. The sample volume will be positioned at or 1 cm within the mitral leaflet's septal and lateral insertion sites. 6. Left atrial volume and left atrial volume index (LAVI) - The maximal left atrial (LA) volume measured from the apical four-chamber view using the modified Simpson method in end-systole before mitral valve opening. The LAVI obtained for all patients by dividing the LA volume by the body surface area. Biochemical measurements: Peripheral blood samples were obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level. Follow up 2D Doppler echocardiography: All previous echocardiographic measurements will be repeated at 40 days of the event.
Study Type
OBSERVATIONAL
Enrollment
80
* Measurements will be 1. Pulsed wave (PW) Doppler 2. E (early diastolic)/A (late diastolic) - Using PW Doppler 3. IVRT (isovolumic relaxation time) 4. Deceleration time (DT) - from the peak of E wave to baseline. 5. E/e'- PW tissue Doppler imaging (TDI) 6. Left atrial volume and left atrial volume index (LAVI) * Peripheral blood samples will be obtained within 48 hours after acute MI, and the serum will be frozen at -70°C until tested for Galactin-3 level.
Faculty of Medicine Assiut University
Asyut, Asyut Governorate, Egypt
RECRUITINGAcute effect of PPCI in STEMI patients on diastolic function and Galactin-3 level
Determine the acute effect of PPCI in STEMI patients on the level of Galectin 3 and diastolic function within 48 hrs of the event.
Time frame: 48 hrs
Correlation to patients' outcomes especially in those with initial high serum Galactin-3
Correlating effect of PPCI on patients outcomes and impact on diastolic function, with consideration to those with initial high serum galectin levels at 40 days of the procedure.
Time frame: 40 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.