Myocardial Work for Prediction of Left Ventricular Remodeling in Patients With STEMI

RenJi Hospital98 enrolled

Overview

The study intends to investigate the alteration of regional myocardial work in patients with acute anterior myocardial infarction underwent primary percutaneous coronary intervention (PCI), and compare the distribution of regional myocardial work in patients with/without early remodeling at acute phase and 3-month follow-up.

Study Type

OBSERVATIONAL

Enrollment

Conditions

ST-Segment Elevated Myocardial Infarction

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom; * Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade. Exclusion Criteria: * significant valvular disease; * cardiomyopathy; l * left bundle branch block; * atrial fibrillation; * previous myocardial infarction (MI); * history of cardiac surgery; * pacemaker implantation.

Locations (1)

Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Delta-work efficiency by echocardiography

A novel tool for non-invasive myocardial work(MW) assessment has been introduced to evaluate myocardial performance.MW was calculated as a function of time through a combination of LV global longitudinal strain(GLS) data and an estimated LV pressure curves. Work efficiency (WE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.The values of culprit regional WE was expressed as WE-LAD.The values of non-culprit regional WE was expressed as WE-nonLAD.The absolute differences of the WE was calculated as the values of non-culprit regional WE minus the values of culprit regional WE, and noted as delta-WE.

Time frame: 24-72 hours after PCI

Secondary Outcomes

Global work index by echocardiography

Global work index (GWI) is classified as total work within the area of the LV pressure-strain loop calculated from mitral valve closure to mitral valve opening.

Time frame: 24-72 hours, 3-month after PCI

Global constructive work by echocardiography

Global constructive work (GCW) was defined as work contributing to LV ejection performed during shortening in systole and work performed during lengthening in isovolumic relaxation.

Time frame: 24-72 hours, 3-month after PCI

Global work efficiency by echocardiography

Global work efficiency (GWE) was calculated from the ratio of the constructive work to the sum of constructive and wasted work, expressed as a percentage.

Time frame: 24-72 hours, 3-month after PCI

Work index-LAD

Work index in left anterior descending(LAD) territory.

Time frame: 24-72 hours, 3-month after PCI

Data from ClinicalTrials.gov

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