The Effect of Cold Exposure on Energy Expenditure

Maastricht University26 enrolled

Overview

Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health. Cold acclimation may alter cold-induced thermogenesis due to changes in (non)shivering thermogenesis and blood flow. The main aim of this research is to compare the energy expenditure responses, during a standardised cold stress (\~ 9°C air temperature, maximum 1 hour), of Siberian adults with Western European adults. The subjects will be individually matched for age, sex, body mass and height. It was hypothesised that cold-induced thermogenesis will be reduced in the Siberian population.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Cold Exposure

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Signed informed consent * Western European origin or of Siberian origin * BMI between 18.5 and 35 kg/m2 * Generally healthy (determined by dependent physician) Exclusion Criteria: * Smoking * Active, uncontrolled cardiovascular disease or cancer * Raynaud's disease * Participation in another biomedical study within 1 month before the first study * Cold-acclimated (Western European group), such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study * Medication use known to hamper subject's safety during study procedures * Abuse of alcohol or drugs