Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health. Cold acclimation may alter cold-induced thermogenesis due to changes in (non)shivering thermogenesis and blood flow. The main aim of this research is to compare the energy expenditure responses, during a standardised cold stress (\~ 9°C air temperature, maximum 1 hour), of Siberian adults with Western European adults. The subjects will be individually matched for age, sex, body mass and height. It was hypothesised that cold-induced thermogenesis will be reduced in the Siberian population.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
26
Cold air exposure (\~ 9°C, maximum 1 hour duration)
Maastricht University
Maastricht, Netherlands
Cold-induced thermogenesis
Energy expenditure with indirect calorimetry
Time frame: 30 min before and during the cold exposure (maximum 1 hour)
Skin temperature
Skin temperature determined with iButtons, measured in °C
Time frame: 30 min before and during the cold exposure (maximum 1 hour)
Core temperature
Core temperature determined with a gastrointestinal pill, measured in °C
Time frame: 30 min before and during the cold exposure (maximum 1 hour)
Shivering activity
Electromyography will be used to measure the electrical activity of 3 skeletal muscles
Time frame: 30 min before and during the cold exposure (maximum 1 hour)
Substrate oxidation
Carbohydrate and fat oxidation will be determined with indirect calorimetry
Time frame: 30 min before and during the cold exposure (maximum 1 hour)
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