The purpose of this study is to determine how different behavioral interventions designed to alter food perceptions and behaviors affect brain responses to food, eating behaviors, and body weight.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
228
Approximately 10-minute behavioral intervention
Approximately 10-minute behavioral intervention
Approximately 10-30 minute behavioral intervention
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
RECRUITINGPercent Change in Blood Oxygen Level Dependent (BOLD) Response to Visual Food Cues as Measured by Functional Magnetic Resonance Imaging
Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, and prefrontal cortex.
Time frame: Baseline, 12 weeks
Change in Food Image Ratings
Food image ratings change from baseline to after the 12-week intervention. Food images are rated on "desire to eat" by visual analogue scale (0-100), with higher scores indicating greater desire to eat.
Time frame: Baseline, 12 weeks
Change in Food Intake
Food intake change from baseline to after the 12-week intervention. Food intake will be measured as total calories consumed during an ad libitum meal.
Time frame: Baseline, 12 weeks
Percent Change in Body Weight
Percent change in body weight (kg) from baseline to after the 12-week intervention.
Time frame: Baseline, 12 weeks
Change in Fat Mass
Change in fat mass, as measured using dual-energy x-ray absorptiometry, from baseline to after the 12-week intervention.
Time frame: Baseline, 12 weeks
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