Muscle Typology and Strength Training Adaptations

University Ghent60 enrolled

Overview

The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers. Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Muscle Fiber Type Exercise Training Frequency

Interventions

Muscle typology + exercise trainingOTHER

Exercise training: Participants perform 9 weeks of strength training at 60% of their 1RM.

Muscle typology + training frequencyOTHER

Training frequency: leg A and arm A of the participants train 3 times per week, leg B and arm B train 2 times per week.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Fast or slow muscle typology * 18 - 45 years old * no strength training experience Exclusion Criteria: * Vegan/vegeterian diet * Supplement intake * chronic diseases * Hypertension, * Smoking * Medication use * Coagulation disorder, infectious diseases

Locations (1)

Department of Movement and Sports Sciences, Ghent University

Ghent, Oost-Vlaanderen, Belgium

Outcomes

Primary Outcomes

Change from baseline muscle volume at 9 weeks

Muscle volume of the legs and the upper arms - MRI

Time frame: Pre and post the 9 weeks training period

Change from baseline dynamic muscle strength at 3 weeks

Upper legs and upper arms - strength training devices

Time frame: Pre, mid and post 9 weeks training period

Change from baseline dynamic muscle strength at 6 weeks

Upper legs and upper arms - strength training devices

Time frame: Pre, mid and post 9 weeks training period

Change from baseline dynamic muscle strength at 9 weeks

Upper legs and upper arms - strength training devices

Time frame: Pre, mid and post 9 weeks training period

Change from baseline isometric muscle strength at 9 weeks

Upper legs and upper arms - Biodex