Inflammatory Markers: HOLEP Versus TURP

Adana City Training and Research Hospital50 enrolled

Overview

Aim of the study is to compare the systemic inflammatory markers and surgical stress response in patients undergoing HOLEP or TUR-P surgery.

Benign prostatic hyperplasia (BPH) is the most common disease in aging men worldwide, causing significant difficulties and resulting in bladder outlet obstruction. Basically, surgical techniques in patients with BPH are transurethral resection of the prostate (TURP), holmium laser enucleation of the prostate (HOLEP), and open prostoactemy surgery. There are many studies comparing the clinical outcomes of TURP and HOLEP surgery. However, to the best of our knowledge, there has not been a study comparing the effects of these two types of surgery on inflammatory markers and stress hormones.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Prostate Hyperplasia

Interventions

Surgery methodPROCEDURE

Patients were subdivided into two groups according to their prostate volume

Eligibility

Sex: MALE

Medical Language ↔ Plain English

Inclusion Criteria: * ASA scores I-III patients * having benign prostatic hyperplasia * undergoing HOLEP or TURP surgery under general anesthesia Exclusion Criteria: * immune system disease, * diabetes mellitus, * malignancy other than prostate disease, * history of steroid use,

Locations (1)

Adana City Training and Research Hospital

Adana, Turkey (Türkiye)

Outcomes

Primary Outcomes

inflamatory markers

WBC (109 /L)

Time frame: Change from baseline WBC (109 /L) at postoperative 0th and postoperative 24th hour

Stress hormone levels

Adrenaline (ng/L)

Time frame: Change from baseline adrenaline (ng/L) at postoperative 0th and postoperative 24th hour

inflamatory markers

CRP

Time frame: Change from baseline CRP (mg/L) at postoperative 0th and postoperative 24th hour

inflamatory markers

IL-6 (pg/ml) and TNF-alfa (pg/ml)

Time frame: Change from baseline IL-6 (pg/ml) and TNF-alfa (pg/ml), at postoperative 0th and postoperative 24th hour

inflamatory markers

CD4+/CD8+

Time frame: Change from baseline CD4+/CD8+ at postoperative 0th and postoperative 24th hourL-6 (pg/ml) and TNF-alfa (pg/ml)

stress hormone levels

Cortisol (microg/dl)

Time frame: Change from baseline cortisol (microg/dl) at postoperative 0th and postoperative 24th hour

Data from ClinicalTrials.gov

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