The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact of elevated oxidative stress on this associations.
Study Type
OBSERVATIONAL
Enrollment
50
Osijek University Hospital
Osijek, Croatia
RECRUITINGSystemic microvascular function in children
Skin microvascular reactivity assessed by Laser Doppler flowmetry (post-occlusive reactive hyperemia, iontophoresis of acetylcholine and sodium nitroprusside) - measured in perfusion units (PU)
Time frame: Day 1.
Systemic macrovascular function in children
Vascular ultrasound measurement of brachial artery response to vascular occlusion (flow mediated dilation; FMD, %)
Time frame: Day 1.
Cerabral vascular function in children
Cerebral blood flow velocities assessed by transcranial Doppler sonography (cm/s)
Time frame: Day 1.
Oxidative stress - thiobarbituric acid reactive substances (TBARS)
Serum sample collection for measurement of biomarkers of oxidative stress level. Thiobarbituric acid reactive substances (TBARS) - biomarker of lipid peroxidation.
Time frame: Day 1.
Endocan
Serum sample collection for ELISA measurement of serum endocan level - proteoglycan associated with endothelium activation
Time frame: Day 1.
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