Pancreatico-duodenectomy is one of the commonly performed procedure for periampullary/distal cholangio/head of pancreas carcinoma. Post operative pancreatitis is an emerging concept, recently being studied as one of the most important contributing factor of Post-operative pancreatic fistula, which is one of the major complication of pancreatoduodenectomy. Rectal indomethacin, a type of non-steroidal anti-inflammatory drug, when given in a single dose has been shown to prevent pancreatitis in patients undergoing ERCP. In this study, we will be administering rectal indomethacin at the time of induction of anesthesia to the experimental arm of the study and compare the results in terms of incidence of post-operative pancreatitis in the two groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
44
100mg Indomethacin Suppository administered at the time of Induction
Standard Medical Treatment
Institute of Liver & Biliary Sciences
New Delhi, National Capital Territory of Delhi, India
Post-operative Pancreatitis
Time frame: first 30 days following pancreatoduodenectomy
Post-operative Pancreatic Fistula
Time frame: first 30 days following pancreatoduodenectomy
delayed gastric emptying
Time frame: First 30 days following pancreatoduodenectomy
intra-abdominal abscess
Time frame: first 30 days following pancreatoduodenectomy
Length of ICU stay
Time frame: First 30 days following pancreatoduodenectomy
Length of hospital stay
Time frame: First 30 days following pancretoduodenectomy
risk factors of post-operative pancreatitis
Time frame: first 30 days following pancreatoduodenectomy
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