Comparison of PET Imaging Patterns With PSMA and AR Expression in Prostate Cancer and Bladder Cancer

Inclusion Criteria: Cohort A: * Age 18-75 years * Histologically or cytologically confirmed adenocarcinoma of the prostate with very high risk for the development of metastases (defined as PSA ≥20 or Gleason Score ≥8 or ≥cT3) and/or oligometastatic (T any, N positive, M any or T any, N any, M positive) * Eastern Cooperative Oncology Group (ECOG) Performance Status grade 0 or 1 * Planned radical prostatectomy * ≤ 5 osseous metastasis * Signed and dated informed consent document indicating that the patient (or legally acceptable representative) has been informed of all pertinent aspects of the trial prior to study participation * Willingness and ability to comply with scheduled visits, treatment plans, laboratory and radiographic assessments, and other study procedures Cohort B - mCRPC: * Age ≥ 18 years * Histologically or cytologically confirmed prostate adenocarcinoma. * Presence of skeletal or nodal metastases according to one of the following criteria: * Confirmed pathological fracture related to the disease OR * Confirmation of distant bone and/or nodal metastases on CT or MRI scan or bone scintigraphy. OR * Positive pathology report of metastatic lesion. * Disease progression despite ADT as indicated by: * PSA increase that is ≥ 2 ng/mL and ≥ 25% above the minimum PSA as reached during ADT or above the pre-treatment level, if no response was observed and which is confirmed by a second value 1 or more weeks later. OR * Progression of measurable lymph nodes (short axis ≥ 15 mm) or visceral lesion measurable per RECIST OR * New metastatic lesions appearing on bone scan/imaging * Chemical or surgical castration * Eastern Cooperative Oncology Group (ECOG) Performance status 0-2. * Signed and dated informed consent document indicating that the patient (or legally acceptable representative) has been informed of all pertinent aspects of the trial prior to study participation * Willingness and ability to comply with scheduled visits, treatment plans, laboratory and radiographic assessments, and other study procedures Cohort C: * Age ≥ 18 years * Histologically or cytologically confirmed prostate adenocarcinoma. * Planned radical prostatectomy * Signed and dated informed consent document indicating that the patient (or legally acceptable representative) has been informed of all pertinent aspects of the trial prior to study participation * Willingness and ability to comply with scheduled visits, treatment plans, laboratory and radiographic assessments, and other study procedures Cohort D: * Age ≥ 18 years * Histologically or cytologically confirmed bladder cancer. * Planned radical cystectomy * Signed and dated informed consent document indicating that the patient (or legally acceptable representative) has been informed of all pertinent aspects of the trial prior to study participation * Willingness and ability to comply with scheduled visits, treatment plans, laboratory and radiographic assessments, and other study procedures Exclusion Criteria: Cohort A: * Tumour infiltration of the rectum or pelvic wall * Visceral metastasis * HIV positive * Any contraindication for surgery * Any other condition that, in the opinion of the Investigator, would impair the patient's ability to comply with study procedures. * Any contraindication for performing a PET/MRI scan (if applicable) * Patient's not eligible for the size of the PET/MRI gantry Cohort B - mCRPC: * HIV positive * Any contraindication for tissue biopsy (if tissue biopsy is planned) * Any contraindication for surgery (if surgery is planned) * Any other condition that, in the opinion of the Investigator, would impair the patient's ability to comply with study procedures. * Any contraindication for performing a PET/MRI scan (if applicable) * Patient's not eligible for the size of the PET/MRI gantry Cohort C: * Any contraindication for surgery * Any other condition that, in the opinion of the Investigator, would impair the patient's ability to comply with study procedures. * Any contraindication for performing a PET/MRI scan (if applicable) * Patient's not eligible for the size of the PET/MRI gantry Cohort D: * Any contraindication for surgery * Any other condition that, in the opinion of the Investigator, would impair the patient's ability to comply with study procedures. * Any contraindication for performing a PET/MRI scan (if applicable) * Patient's not eligible for the size of the PET/MRI gantry