This study aims to evaluate the efficacy of immunosuppressive agents treating Thyroid Associated Ophthalmopathy by multi-model image.
Thyroid Associated Ophthalmopathy is one of autoimmune orbital diseases characterized by enlargement of the extraocular muscles and increase in fatty or/and orbit connective tissue volume affecting the appearance and visual function of the eyes. TAO can be classified into active phase and inactive phase according to the activity score and wait-and-see or surgery are widely chosen for patients in inactive phase. A great number of patients in inactive phase becoming refractory and reoccurring. Until now, the improvement of TAO is still be measured subjectively with low reliability and less accuracy. Multi-modal image is a new method to assess both the appearance and visual function of TAO and some of the indexes can be regarded as more apparent and stable in assessing the efficacy and prognosis of TAO. This perspective cohort study aims to evaluate the efficacy of immunosuppressive agents in TAO by multi-model image and function assessments.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
12
patients with TAO recruited in this study will administrated with immunosuppressive agent per day
Zhongshan Ophthalmic Center
Guangzhou, Guangdong, China
RECRUITINGchange of macular sensibility
the same investigator uses the same instrument to assess the macular sensibility. The better change of macular sensibility means the better outcome.
Time frame: At 6 months
change of extraocular muscle volume and orbital fat volume by MRI
A 3D MRI reconstructive model will be established and the volume of extraocular muscle and orbital fat will be calculated by the same advanced programmer who is blinded of the pre- or post- treatment images order. The higher the value changes, the better the outcome is.
Time frame: at month 6
change of proptosis
proptosis will be measured by the same investigator using the same Hertel instrument
Time frame: at month 6
change of QoL
the score of quality of life will be assessed by the same investigator using GO-QoL. The higher change of quality of life means the better outcome.
Time frame: at month 6
change of eyelid aperture and lid lag
the values will be measured by the same investigator using the same millimeter ruler and the higher change of eyelid aperture and lid lag means the better outcome
Time frame: at month 6
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