To evaluate neurological findings with TSPO-PET and MRI in patients who have been exposed to indoor air pollutants and have potentially neurological symptoms.
Health problems related to indoor air pollutants have been studied for several decades but there is still not sufficient scientific evidence to prove the association between many of the described symptoms and exposure to mold and other air pollutants. This research aims on studying the activation of microglia and inflammation in the brains of individuals exposed to indoor air pollutants having neurological symptoms with MRI and TSPO-PET imaging, questionnaires and biomarkers and compare the findings to individuals having neurological conditions without exposure to indoor air pollutants as well as healthy controls.
Study Type
OBSERVATIONAL
Enrollment
35
Turku PET Centre
Turku, Southwest Finland, Finland
[11C]PK11195 binding in the brain
Change in microglial activity in the brains of the individuals in different study groups as measured by \[11C\]PK11195 PET imaging
Time frame: Baseline
DTI-MRI metrics
To evaluate the microstructural damage of the brain between individuals in different groups
Time frame: Baseline
Results from questionnaires
Questionnaires about quality of life compared between the indoor air pollutant and neurological symptoms groups
Time frame: Baseline
Blood biomarkers
Biomarkers measured from blood to assess the possible inflammatory state of individuals in different study groups
Time frame: Baseline
Neurography measures
Done additionally if clinical studies indicate necessary, to assess the state of peripheral nerves
Time frame: Baseline
Electromyography measures
Done additionally if clinical studies indicate necessary, rating each examined muscle as normal/myopathic/neuropathic
Time frame: Baseline
Cerebrospinal fluid biomarkers
Biomarkers measured from cerebrospinal fluid to assess the possible inflammatory state of individuals in different study groups
Time frame: Baseline
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