A Study to Evaluate White Matter Hyperintensities in Migraine

Inclusion Criteria - Migraine (N=20): * Female only. * Ages 20-45 years. * Presence of WMH on MRI. Exclusion Criteria: * History of SVI and/or history of MS or other neurological disease other than migraine. * History of cancer or organ transplantation. * Contraindication to MRI. * Pregnancy. * History of abnormal brain MRI other than WMH. * Subjects not willing to comply with the study procedures will be removed from the study. Inclusion Criteria - SVI disease (n=10): * Female only * Ages \> 60 years. * Presence of WMH on MRI. Exclusion Criteria: * History of migraine and/or history of MS or other neurological disease other than SVI. * History of cancer or organ transplantation. * History of abnormal brain MRI other than WMH. * Pregnancy. * History of abnormal brain MRI other than WMH. * Subjects not willing to comply with the study procedures will be removed from the study. Inclusion Criteria - MS (n=10): * Female only. * Ages 20-45. * Presence of WMH on MRI. Exclusion Criteria: * History of migraine and/or history of SVI or other neurological disease other than MS. * History of cancer or organ transplantation. * History of abnormal brain MRI other than WMH. * Pregnancy. * History of abnormal brain MRI other than WMH. * Subjects not willing to comply with the study procedures will be removed from the study.