Pulmonary Langerhans cell histiocytosis (PLCH) is a rare disease, of unknown etiology, that occurs almost exclusively in smokers.The clinical experience suggests a high prevalence of anxiety symptoms and an addictive profile. However, no study to date has precisely investigated the prevalence of co-morbid psychiatric disorders in this population.The aim of the study is to evaluate the prevalence of co-morbid psychiatric disorders in adult PLCH patients. This study should allow: * to assess the prevalence of psychiatric disorders co-morbid in PLCH patients * a targeted and more effective management of patients * a better response rate to smoking and cannabis weaning, that represents a major goal for these patients.
Study Type
OBSERVATIONAL
Enrollment
100
Added scales : * Mini Internationnal Neuropsychiatric Interview * Fagerström test * DSM-5 Scale Additional dosage : - a urine sample will be taken to evaluate the presence of tobacco and nicotine breakdown products and the presence of various toxics Expired carbon monoxide for patients using nicotine substitutes
Hôpital Saint-Louis, Centre de référence national des histiocytoses, Service de Pneumologie
Paris, France
Proportion of patients with at least one of the disorders detailed in the Mini International Neuropsychiatric Interview (MINI) test
The Mini-International Neuropsychiatric Interview (M.I.N.I.) is a structured diagnostic interview (40 minutes duration), exploring in a standardized way the main psychiatric disorders of Axis I of the DSM-IV TR (American Psychiatric Association), namely 14 items with a binary result for each specified disorder
Time frame: at inclusion
Proportion of patients with at least one comorbid addictive disorder among: tobacco, alcohol, cannabis, benzodiazepines, cocaine, opiates
Definition and diagnosis of addictive disorder will be assessed with Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5)
Time frame: at inclusion
Proportion of patients with active tobacco consumption with or without comorbid psychiatric disorder
Tobacco consumption will be assessed by Fagerström survey and DSM-5, cotinine in urine quantification and expired carbon monoxide for patients using nicotine substitutes. Fargerstrom test evaluates the dependence on cigarettes from 0 to 10 (0 indicated a very low dependence and 10 a very strong dependence)
Time frame: at inclusion
Proportion of patients with persistent tobacco consumption despite nicotine replacement treatment
Tobacco consumption will be assessed by Fagerström survey and DSM-5 and expired carbon monoxide for patients with nicotine substitutes
Time frame: at inclusion
Number of previous tobacco weaning episodes and co-morbid psychiatric disorders
Time frame: at inclusion
Number of co-morbid psychiatric disorders
Time frame: at inclusion
Factors associated with psychiatric disorders as assessed by Mini International Neuropsychiatric Interview (MINI) test
The Mini-International Neuropsychiatric Interview (M.I.N.I.) is a structured diagnostic interview (40 minutes duration), exploring in a standardized way the main psychiatric disorders of Axis I of the DSM-IV TR (American Psychiatric Association), namely 14 items with a binary result for each specified disorder
Time frame: at inclusion
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