This project will evaluate the effect of gender-affirming testosterone treatment on how other medications are processed by the body.
Gender-affirming hormone therapy may include testosterone, a hormone that the body creates and uses naturally. Testosterone is prepared as a medication that patients may take to increase hormone levels. Changes in testosterone concentrations in the body may affect how the body processes other medicines. The purpose of this study is to find out how testosterone therapy affects a single tracer dose of approved medicines in the blood (midazolam, digoxin, and acetaminophen) and to confirm testosterone treatment does not affect natural bacterial in the gut.
Study Type
OBSERVATIONAL
Enrollment
12
Oral syrup
Oral tablet
Oral tablet
University of Washington
Seattle, Washington, United States
midazolam AUC ratio (treatment/control)
ratio of the area under of the plasma concentration time curve (AUC) of midazolam in the presence to absence of gender-affirming testosterone treatment.
Time frame: 0-48 hours
midazolam Cmax ratio (treatment/control)
ratio of the maximum plasma concentration (Cmax) of midazolam in the presence to absence of gender-affirming testosterone treatment
Time frame: 0-48 hours
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