This study includes two parts (Single Ascending Dose, SAD; Multiple-Ascending Dose, MAD) and enrolls healthy participants. Participants in SAD accept single subcutaneous (SC) injection of HS-20094 and participants in MAD accept SC injection of HS-20094 once weekly for 4 weeks. The main purpose of this study is to determine 1) The safety of HS-20094; 2) How much HS-20094 gets into the bloodstream and how long it takes the body to get rid of it.3) How HS-20094 affects the levels of blood sugar, insulin and weight.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
68
Beijing University First Hospital
Beijing, Beijing Municipality, China
RECRUITINGIncidence of adverse event (AE), serious adverse event (SAE), AE leading to study discontinuation, AE severity and relation with study drug
A summary of AEs and SAEs, AE leading to study discontinuation, AE severity and relation with study drug will be reported in the reported adverse events module
Time frame: Time of Inform Consent Form to Day 29 (SAD) or Day 50 (MAD)
Pharmacokinetics (PK): Cmax of HS-20094
PK: Cmax of HS-20094
Time frame: Baseline to Day 22 (SAD) or Day 43 (MAD)
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve (AUC) of HS-20094
PK: AUC of HS-20094
Time frame: Baseline to Day 22 (SAD) or Day 43 (MAD)
Pharmacokinetics (PK): Tmax of HS-20094
PK: Tmax of HS-20094
Time frame: Baseline to Day 22 (SAD) or Day 43 (MAD)
Pharmacodynamics (PD): AUC of glucose
PD: AUC of glucose
Time frame: Day 22 (MAD)
Pharmacodynamics (PD): AUC of insulin
PD: AUC of insulin
Time frame: Day 22 (MAD)
Weight change
Time frame: baseline to Day 29 (SAD) or Day 50 (MAD)
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