A Long-term Survival Analysis of Different Surgical Method in Early Hepatocellular Carcinoma

Chen Xiaoping369 enrolled

Overview

The investigators established three prospective cohorts of patients with BCLC stage 0-A HCC, based on different surgical approaches (open, laparoscopic and robotic). After 5 years of follow-up, the investigators used propensity score matching (PSM) to reduce selection bias and then compared the long-term oncological outcomes of the three different surgical approaches, which might provide high-level evidence in non-randomized observational studies.

In this study, three prospective cohorts of patients with BCLC stage 0-A HCC, underwent complete liver resection using different surgical approaches (OLR, LLR, and RALR), were established. After adequate periods of follow-up, the long-term oncological outcomes of the three different surgical approaches were compared, providing a higher level of evidence using a non-randomized comparative study based on propensity score matching (PSM) analysis.

Study Type

OBSERVATIONAL

Enrollment

369

Conditions

Long-term Effects of Cancer Treatment

Interventions

liver resectionPROCEDURE

After adequate periods of follow-up, the long-term oncological outcomes of the three different surgical approaches were compared, providing a higher level of evidence using a non-randomized comparative study based on propensity score matching (PSM) analysis.

Eligibility

Sex: ALLMin age: 14 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All HCC patients in BCLC stage 0-A underwent liver resection in hepatic surgery center, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology. The inclusion criteria were as follows: 14- 75 years old Exclusion Criteria: * with any history of malignant tumors; with treatment of ablation, TACE or TKI history before liver resection.

Locations (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Outcomes

Primary Outcomes

Overall Survival

The primary outcomes of this study included long-term oncological outcomes of OS

Time frame: 14/02/2015-30/06/2021

Disease free Survival

The primary outcomes of this study included long-term oncological outcomes of DFS

Time frame: 14/02/2015-30/06/2021

Secondary Outcomes

postoperative complications

Postoperative morbidity and mortality were assessed according to the Clavien-Dindo classification

Time frame: 14/02/2015-30/06/2021

Textbook Outcome in liver surgery (TOLS)

Textbook Outcome in liver surgery (TOLS), was defined as the absence of intraoperative incidents of grade 2 or higher, postoperative bile leak grade B or C, severe postoperative complications, readmission within 30 days after discharge, in-hospital mortality, and the presence of R0 resection margin.

Time frame: 14/02/2015-30/06/2021

Data from ClinicalTrials.gov

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