Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?

University Hospital, Basel, Switzerland1,554 enrolled

Overview

This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection. Specifically, it is to analyze the outcome of the Infection Likely group and compare it to the Infection Unlikely group as well as other subgroups within previous validated definitions (Musculoskeletal Infection Society (MSIS)/International Consensus on Musculoskeletal Infection (ICM) 2013 and ICM 2018).

Periprosthetic joint infection (PJI) is a major burden for healthcare systems. The European Bone and Joint Infection Society (EBJIS) proposed a new set of criteria introducing a three level 'traffic light' distinction: Infection Unlikely, Infection Confirmed but also an intermediate group called Infection Likely (but nor confirmed). This retrospective multi-center, multi-national cohort study is to validate the EBJIS Definition of Prosthetic Joint Infection. Specifically, it is to analyze the outcome of the Infection Likely group and compare it to the Infection Unlikely group as well as other subgroups within previous validated definitions (Musculoskeletal Infection Society (MSIS)/International Consensus on Musculoskeletal Infection (ICM) 2013 and ICM 2018).

Study Type

OBSERVATIONAL

Enrollment

1,554

Conditions

Periprosthetic Joint Infection (PJI)

Interventions

data collection to classify infection statusOTHER

Review of medical records of all selected cases (TKA/THA patients) to classify infection status according to different classifications (EBJIS, MSIS/ICM 2013, ICM 2018).

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * THA/TKA patients that underwent revision surgery regardless of final aseptic vs. infected diagnosis between 01.01.2013 until 31.12.2018 Exclusion Criteria: * less than two years follow up * less than four intraoperative microbiology samples (synovial fluid, tissue samples, implant sonication) * no preoperative/intraoperative synovial fluid differential leukocyte count

Locations (2)

Centro Hospitalar do Porto, Porto, Portugal

Porto, Portugal

University Hospital Basel, Orthopedics and Traumatology

Basel, Switzerland

Outcomes

Primary Outcomes

Prosthetic Joint Infections (with or without the need for further surgery)

Number of Prosthetic Joint Infections (with or without the need for further surgery) among each PJI definition ("Infection Unlikely", "Infection Confirmed", "Infection Likely (but nor confirmed)"