This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of potassium abnormalities.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Enrollment
14,989
Once the AIDE indicates high risk of dyskalemia, an obvious message by scarlet letter was appeared in the HIS operation interface to corresponding physicians. To avoid the alert fatigue, we selected the cut-off points with expected positive predictive values of ≥40% according to previous data, which was the consensus of enrolled physicians before the trial considering the clinical loading. The physicians received the AIDE alerts as long as they were operating HIS logged in by their account, even if they were caring other patients. Physicians can review the AIDE predictions of patients in the intervention group. Therefore, this was a single-blind study since HIS presented different information for patients in intervention and control groups. The participated physicians understood the likelihood of dyskalemia and cardiac risk for those patients with ECG-dyskalemia, and provided suitable medical care according to patients' conditions.
National Defense Medical Center
Taipei, Taiwan
Cumulative proportion of hyperkalemia treatment
Calcium supplement, insulin, potassium binding resin, β2-agonist, loop diuretics, sodium bicarbonate, and hemodialysis.
Time frame: Within 3 hours
Cumulative proportion of hypokalemia treatment
Intravenous potassium chloride, oral potassium gluconate, and oral potassium chloride
Time frame: Within 3 hours
Cardiac arrest (sudden death)
Cardiac arrest (sudden death)
Time frame: Within 3 days
Cumulative proportion of All-cause mortality
All-cause mortality
Time frame: Within 365 days
Cumulative proportion of electric shock
Cardioversion
Time frame: Within 6 hours
Cumulative proportion of CPR event
Cardiopulmonary pesuscitation
Time frame: Within 6 hours
Cumulative proportion of Discharge
Discharge from inpatient department or emergency department
Time frame: Within 14 days
Cumulative proportion of Treatment-induced hypokalemia event
Treatment-induced hypokalemia event
Time frame: Within 24 hours
Cumulative proportion of Treatment-induced hyperkalemia event
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Treatment-induced hyperkalemia event
Time frame: Within 24 hours