Study to Assess the Real World Effectiveness of Inclisiran in Chinese Adult Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia

Inclusion Criteria: Inclisiran Cohort Patients eligible for inclusion in this study must meet all of the following criteria. 1. Confirmed diagnosis of primary hypercholesterolemia or mixed dyslipidemia 2. Age ≥ 18 years at baseline 3. Initiated treatment with inclisiran according to the decision of both physician and patient 4. Signed informed consent(s) must be obtained prior to participation in the study SoC Historical Cohort Patients eligible for inclusion in this study must meet all of the following criteria. 1. Confirmed diagnosis of primary hypercholesterolemia or mixed dyslipidemia, with which reference to LDL-C \> 70 mg/dL (1.8 mmol/L) 2. Age ≥ 18 years 3. Compliance with the standard lipid-lowering therapy, which is defined as a change from prior lipid-lowering therapy to an optimal lipid-lowering regimen, with the date of compliance with standard lipid-lowering therapy after January 1, 2017 as the index date 4. With available LDL-C test at baseline, which is defined as the closest LDL-C test to the index date within 6 months prior to the index date 5. With available LDL-C test on D90 (90±60 days) or D330 (330±90 days) after the index date Exclusion Criteria: Inclisiran Cohort Patients meeting any of the following criteria are not eligible for inclusion in this study. 1. Treatment with monoclonal antibodies directed towards PCSK9 within 90 days before first visit (V1) 2. Severe hepatic impairment (Child-Pugh class C) 3. Severe renal impairment (eGFR ≤ 30 mL/min), and/or on hemodialysis 4. Participation in any cardiovascular clinical trial, concurrent or within the last 30 days of the baseline 5. Females who are pregnant or nursing, or who are preparing for pregnancy 6. Hypersensitivity to the active substance or to any of the excipients of inclisiran solution SoC Historical Cohort Patients meeting any of the following criteria are not eligible for inclusion in this study. 1. Treatment with monoclonal antibodies directed towards PCSK9 during research period 2. Severe hepatic impairment (Child-Pugh class C) 3. Severe renal impairment, (eGFR ≤ 30 mL/min), and/or on hemodialysis 4. Participation in any cardiovascular clinical trial during research period 5. Females who are pregnant or nursing during research period