Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock

Xiangya Hospital of Central South University62 enrolled

Overview

Objectives: Comparison of microcirculation indexes and hemodynamic indexes to guide resuscitation in patients with septic shock. Intervention: 1. Microcirculation-oriented resuscitation group: When the system hemodynamics meets the standard of EDGT, the microcirculation-oriented resuscitation group will evaluate the organ perfusion level and adjust the hemodynamic therapy according to the sublingual microcirculation parameters (PPV \> 68%). 2. Control group: The standard treatment group will adjust the shock management scheme through systemic hemodynamic parameters. Primary outcome: (1)change in SOFA score at 72h (2)30-day mortality

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Sepsis

Interventions

sublingual microcirculation,DEVICE

Avoiding pressure artifacts, clear stable microvascular images were taken for a minimum of 20 seconds of the left, middle, and right sections of the tongue.

hemodynamic monitoringDEVICE

Arterial blood lactic acid (Lac), central venous oxygen saturation (ScvO2), hematocrit (HCT) and entral venous-to-arterial carbon dioxide partial pressure difference (Pcv-aCO2) will be measured employing a bedside blood gas machine on admission and six hours following admission.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients fulfilled the diagnostic criteria of septic shock. Exclusion Criteria: * declined to participate * pregnant * patients who were younger than 18 years old * active bleeding * septic shock is diagnosed for more than 4 hours * patients are expected to be die within 24hours

Locations (1)

Xiangya Hospital of Central South University

Changsha, Hunan, China

RECRUITING

Outcomes

Primary Outcomes

change in SOFA score

△SOFA

Time frame: 72h

Secondary Outcomes

30-day mortality

mortality

Time frame: 30d

Central Contacts

Lina Zhang, MD.

CONTACT

+8615874875763 zln7095@163.com

Data from ClinicalTrials.gov

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