Sequelae of COVID-19 With Focus on Exercise Capacity and Underlying Mechanisms

Arno Schmidt-Trucksäss128 enrolled

Overview

The project is designed as a cross-sectional study and aims to examine long-term consequences of coronavirus disease 2019 (COVID-19) for selected bio-behavioural parameters while taking the disease course severity into account.

Study Type

OBSERVATIONAL

Enrollment

128

Conditions

Patients Post-COVID-19 Controls

Interventions

Cardiorespiratory fitnessDIAGNOSTIC_TEST

Cardiopulmonary exercise testing

Lung functionDIAGNOSTIC_TEST

Body plethysmography

Muscular strength and balance testsDIAGNOSTIC_TEST

Handgrip strength test, mid-thigh pull test and standing balance test in static tandem stance

Eligibility

Sex: ALLMin age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * tested positive for SARS-CoV-2 using antigen- or PCR tests within the last 18 months * previous hospitalisation due to COVID-19 * fully vaccinated (only for controls) Exclusion Criteria: * inability to follow the study procedures (e.g. due to language barriers, psychological disorders, dementia, etc.), * known pregnancy or lactating women, * presence of any contraindications for exercising until maximum exhaustion, including insufficient blood pressure control (systolic \>170 mmHg, diastolic \>100 mmHg), ongoing cancer treatment, unstable angina pectoris, uncontrolled bradyarrhythmia or tachyarrhythmia, severe uncorrected valvular heart disease, clinically relevant acute infection, any form of musculoskeletal injury, * participating in any interventional clinical trial within the last four weeks, * previous participation in the current study * history of symptomatic COVID-19 (only for controls)

Locations (1)

Division of Sports and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel

Basel, Canton of Basel-City, Switzerland

RECRUITING