Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans

N/ACompletedNCT05119153

North Carolina State University19 enrolled

Overview

The present study determined the effects light, medium, and dark roasted, brewed coffees on blood glucose responses in normal (n = 19) subjects.

This is a single-blinded, randomized partial block design conducted over 6 weeks in two parts. In part 1 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a beverage containing 50 g of glucose. In part 2 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a standardized breakfast (corn flakes cereal + skim milk) containing 50 g of glucose. In each part, fasting and postprandial glucose profiles were determined.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Hyperglycemia

Interventions

Placebo ComparatorDIETARY_SUPPLEMENT

Placebo designed to mimic coffee color.

Light Roasted CoffeeDIETARY_SUPPLEMENT

12 oz light roast coffee

Medium Roasted CoffeeDIETARY_SUPPLEMENT

12 oz medium roast coffee

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: • Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl. Exclusion Criteria: * Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl. * Weight less than 110 pounds (55 kg) * Pre-existing health conditions, such as: * High cholesterol * Hypertension * Cardiovascular disease * Gastrointestinal motility disorders * Hypo- or hyperthyroidism * Anemia * Renal disease * Liver disease, including hepatitis B or C, cholestasis, cirrhotic liver disease, or non-alcoholic fatty liver disease * Chronic or acute pancreatitis * Diabetes type 1 or 2 * Insulin resistance * Polycystic ovary syndrome * Food allergies or intolerances to coffee/caffeine/dairy/corn-based cereals. * Currently taking prescription medication * Current smoker * Consumes more than 3 alcoholic beverages per day * Pregnant or breastfeeding * Not willing to take their own blood samples with finger sticks

Locations (1)

Schaub Hall, Campus Box 7624

Raleigh, North Carolina, United States

Outcomes

Primary Outcomes

Changes in Blood Glucose

Each week, fasted baseline and postprandial measurements taken out to 240 minutes

Time frame: 6 weeks

Secondary Outcomes

Changes in Glucose Area Under the Curve

Used glucose changes over 240 minutes to construct area under the curve

Time frame: 6 weeks

Data from ClinicalTrials.gov

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