The purpose of this study is to assess the effect of Dexamethasone on postoperative pain and nausea after periacetabular osteotomy.
Bernese periacetabular osteotomy (PAO) is a standard procedure with good mid and long-term results. Postoperative pain is a great concern and postoperative pain management of great importance. High demand for opiates and the associated side effects especially nausea limit the postoperative rehabilitation. Promising results to reduce postoperative pain and nausea have been achieved by perioperative dexamethasone, which has a strong anti-inflammatory effect reducing pain and inflammation as well as a strong anti-emetic effect, especially in total hip replacement. It is our goal to compare the effect of perioperative intravenous dexamethasone (3x 4mg Amp. Fortecortin =12mg prior to surgery and 3x4mg Amp. Fortecortin = 12mg at 8.00am of the first postoperative day) to a control group (placebo) (3ml saline solution postoperative day 1 at 8.00am) regarding pain level, opiate consumption, postoperative nausea and patient satisfaction. A double-blinded prospective randomized control trial including up to 60 patients receiving elective unilateral PAO will be conducted.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
s. arm/group description
s. arm/group description
Uniklinik Balgrist
Zurich, Switzerland
RECRUITINGPostoperative pain level
The VAS Pain score assesses pain Levels on a scale from 0 (no pain) to 10 (worst possible pain).
Time frame: 6 hours postoperatively
Postoperative pain level
The VAS Pain score assesses pain Levels on a scale from 0 (no pain) to 10 (worst possible pain).
Time frame: 24 hours postoperatively
Amount of opiates (morphinequivalent) consumed
The authors will assess the amount of Opiates the Patient needed due to the performed Surgery during the hospital stay.
Time frame: 48 hours postoperatively
Amount of anti-emetics consumed (Ondansetron)
The authors will assess the amount of mg of anti- emetic drugs (Ondansetron) the Patient required during the Hospital stay.
Time frame: 48 hours postoperatively
Patient satisfaction as assessed by the revised American pain society patient outcome questionnaire
Patient satisfaction will be assessed by the revised American pain Society Patient Outcome questionnaire (APS-POQ-R). (0% worst, 100% best)
Time frame: 6 hours postoperatively
Patient satisfaction as assessed by the revised American pain society patient outcome questionnaire
Patient satisfaction will be assessed by the revised American pain Society Patient Outcome questionnaire (APS-POQ-R).(0% worst, 100% best)
Time frame: 24 hours postoperatively
Patient satisfaction as assessed by the revised American pain society patient outcome questionnaire
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Patient satisfaction will be assessed by the revised American pain Society Patient Outcome questionnaire (APS-POQ-R).(0% worst, 100% best)
Time frame: 48 hours postoperatively
Number of vomiting events
The authors will count the number of vomiting events postoperatively as a direct marker for postoperative Nausea.
Time frame: 48 hours postoperatively
Physical therapy milestones 1
First steps in the hallway
Time frame: 1 week postoperatively
Physical therapy milestones 2
Walk up stairs
Time frame: 1 week postoperatively
Physical therapy milestones 3
Bicycle ergometer can be used indipendently by the patient
Time frame: 1 week postoperatively
Length of hospitalization
The length of hospitalization will be obtained from the Patient Chart.
Time frame: 2 weeks