Resilience and Brain Health of Older Adults (MEDEX-2)

N/AEnrolling By InvitationNCT05124132

Washington University School of Medicine468 enrolled

Overview

This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

468

Conditions

Age-related Cognitive Decline

Interventions

Mindfulness-Based Stress Reduction

ExerciseBEHAVIORAL

Exercise

Mindfulness-Based Stress Reduction + ExerciseBEHAVIORAL

Mindfulness-Based Stress Reduction + Exercise

Health EducationBEHAVIORAL

Health Education

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Participated in the parent study, Protocol ID #201410093 Exclusion Criteria: * Inability to safely continue classes or complete assessments, as per PI discretion

Locations (1)

Washington University School of Medicine

St Louis, Missouri, United States

Outcomes

Primary Outcomes

Effects of the interventions on changes in cognitive performance

Test effects of mindfulness and exercise on changes in change in memory and cognitive control composites.

Time frame: Approximately three years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.