TOlerance MOlecular and Genome-wide Studies With Renal Allograft Recipient Material

Université Libre de Bruxelles18 enrolled

Overview

TOMOGRAM is a European multicentric, prospective, experimental, controlled study that aims to increase our understanding of the causative mechanisms of operational tolerance in kidney transplantation through the achievement of several multimodal whole-genomic analysis in human biological samples.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Kidney Transplantation

Interventions

High throughput DNA and RNA sequencingGENETIC

High throughput DNA and RNA sequencing

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * recipient of an allogenic renal allograft, * have experienced (whatever ongoing or not) at least a whole year with blood creatinine \<1.7 mg/dL and proteinuria \</=1g/day or /g creatinine despite the COMPLETE discontinuation of immunosuppressive drugs, * alternatively, have experienced (whatever ongoing or not) at least a whole year with stable blood creatinine (max 20% variation) and proteinuria above these criteria despite the COMPLETE discontinuation of immunosuppressive drugs Exclusion Criteria: * Past medical history of allogeneic bone-marrow transplantation / combined organ transplantation

Outcomes

Primary Outcomes

Number of moderately to highly damaging exonic variants

Time frame: Through study completion, an average of 2 year

Data from ClinicalTrials.gov

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